we all know that stress plays a huge roll in perio. We went through it in one of the revision sessions, does anyone have a simple/perfect answer to the process that occurs with stress making someone more sucseptible to infection/perio?
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- Stress causes activation of the CNS causing release of corticotropin (cortisol CRH) and adrenocorticotropin (ACTH)
ReplyDelete- This depresses immune function releasing pro inflam cytokines increasing infection and risk of perio
- Inadequate coping instigates an acute reaction via the autonomic nervous system where adrenal medulla produces nor epinephrine and epinephrine which further produces pro inflam cytokines (PGE & proteases)
- thus increasing ones susceptibility to perio / infection
As I read that it doesn't sound simple and not sure if its perfect but opens discussion I guess ;) Hope its of some help. Not sure if you have the article Tom but LeResche & Dworkin 'The role of stress in inflammatory disease, including periodontal disease:review of concepts and current findings' has a great diagram.....